Enhanced Immunologic Sensitization of Mice by the Simultaneous Injection of Antigen and Specific Antiserum

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Abstract
Summary: An enhanced immune response to bovine serum albumin (BSA) was elicited only following the injection of complexes formed in antigen excess. The enhanced response to BSA was biphasic; the first peak was dose-dependent, while the second peak was dose-independent. The antigen-antibody ratio is more important in eliciting an enhanced response than the amount of antigen injected. Using the same amount of antigen, immune complexes are much more effective than alum precipitated antigen. An enhanced response to rabbit γ-globulin (RGG) was also elicited using immune complexes. The magnitude of the response was relatively independent of the antigen-antibody ratio and it exhibited a single peak at about 7 to 8 weeks. The responses to RGG and BSA appeared to be noncompetitive.

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