TOLERANCE DEVELOPMENT TO CADMIUM-INDUCED ALTERATION OF DRUG ACTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (1) , 197-200
Abstract
Cd [an environmental pollutant] administration potentiates the duration of hexobarbital-induced hypnosis and inhibits the rate of hepatic microsomal metabolism of this drug in the male rat. The threshold dose of Cd required to produce these alterations in drug action is 0.84 mg Cd/kg. If subthreshold doses of Cd (0.21 or 0.42 mg Cd/kg) are administered prior to the 0.84 mg Cd/kg dose, the Cd-induced alterations in drug action are no longer observed.

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