Insulin Clearance During Hypoglycemia in Patients with Insulin-Dependent Diabetes Mellitus
- 1 July 1991
- journal article
- clinical trial
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 23 (07) , 333-335
- https://doi.org/10.1055/s-2007-1003690
Abstract
Eight male patients with insulin-dependent diabetes mellitus (IDDM) without residual beta-cell function were studied on two occasions in random order. In one experiment hypoglycemia was induced by a constant rate iv infusion of insulin (0.034 U/kg/h) during 150 minutes. At the other occasion an identical infusion of insulin was given, but this time euglycemia was maintained by a variable iv infusion of glucose. Plasma levels of free insulin were almost identical during the two experiments indicating that insulin clearance is not influenced by hypoglycemia in patients with IDDM.Keywords
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