Metabolism of uracil-containing DNA: degradation of bacteriophage PBS2 DNA in Bacillus subtilis
- 1 June 1977
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 22 (3) , 835-838
- https://doi.org/10.1128/jvi.22.3.835-838.1977
Abstract
When B. subtilis is infected by the uracil-containing DNA phage PBS2, the parental DNA labeled with radioactive uracil and cytosine remains acid insoluble. If the synthesis of the phage-induced uracil-DNA N-glycosidase inhibitor [protein] is prevented, the parental DNA is completely degraded to acid-soluble products beginning at about 6 min after infection. The host N-glycosidase probably initiates the degradation pathway, with nucleases being responsible for the remaining degradation of the DNA.This publication has 15 references indexed in Scilit:
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