Liver Damage Concurrent with Iproniazid Administration

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Abstract
IPRONIAZID (1-isonicotinyl-2-isopropyl hydrazine)§ was originally introduced for the treatment of tuberculosis.1 , 2 Because of its toxicity in the dosage employed it has been replaced in the therapy of this disease by its chemical relative, isoniazid.3 4 5 However, its observed effect in these patients as a Central-nervous-system stimulant has led to renewed interest and use of this drug in an ever-increasing number of clinical situations. As a "psychic, energizer" it has been employed in the treatment of depressive and debilitating states, and more recently in the management of hypertension, ulcerative colitis, rheumatoid arthritis and angina pectoris.6 7 8 This report describes the appearance and nature . . .