Metabolic and toxicologic evaluation of 2,3,4,3',4'-pentachlorobiphenyl in rats and mice.

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Abstract
When 2,3,4,3'',4''-pentachlorobiphenyl (PenCB), a component of Kanechlor 400, was administered orally at a single dose of 150 mg/kg or 60 mg/kg to 3 rats, all died in 8 days or 9-11 days after treatment, respectively, with an .apprx. 30% decrease in body weight. Marked disappearance of fat from adipose tissues and severe fatty change in the liver were observed within 3 days after treatment, and became enhanced after 7 days. No metabolites of a phenolic nature could be detected in the feces, urine or tissues, although about 34% of the dose was recovered unchanged in the feces collected for 8 days following administration. Treatment with 2,4,3'',4''-tetrachlorobiphenyl (2,4,3'',4''-TCB) did not induce either a decrease in body weight nor damage of any tissues of the rat. The lethality of PenCB in mice was much weaker than in rats, because the 14 day i.p. LD50 was determined to be 0.40 g/kg. This value is about 5 times as high as that of 2,4,3'',4''-TCB in mice (i.e., LD50 g/kg). [Kdnechlor 400 caused the polychlorinated biphenyl poisoning (called Yusho) in Japan.].