Automated Synthesis of Peptides
- 8 October 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 150 (3693) , 178-185
- https://doi.org/10.1126/science.150.3693.178
Abstract
Peptides have been synthesized by a new method which depends on carrying out the synthetic reactions while the growing peptide chain is bound to an insoluble supporting solid; the method is therefore called "solid-phase peptide synthesis." The idea was originally conceived and developed because it offered distinct advantages in yield, ease of operation, and speed, and these particular qualities were necessary for the eventual automation of the process. An instrument has recently been constructed which performs and controls automatically all the operations necessary for the synthesis of a peptide. The method has been successfully applied to the synthesis of several biologically active peptides, including brady-kinin and angiotensin. Extension of this approach to the synthesis of much larger peptides and possibly even to proteins is predicted.This publication has 47 references indexed in Scilit:
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