Induction of Cytochrome P-450-linked Monooxygenase System in Rat Liver Microsomes by Xiao-Chaihu-Tang
- 1 January 1996
- journal article
- research article
- Published by World Scientific Pub Co Pte Ltd in The American Journal of Chinese Medicine
- Vol. 24 (2) , 143-151
- https://doi.org/10.1142/s0192415x96000190
Abstract
The administration of Xiao-Chaihu- Tang (TJ-9) for 2 weeks induced a 25% increase in the content of cytochrome P-450 in female rat liver microsomes, while the content in male rats remained unchanged. The enzymatic activities toward various xenobiotics were stimulated in female rats, the levels being in the range of 125-250% of those in the control rats. Among these xenobiotics, the metabolic rates for substrates of cytochrome P-450 2El were significantly enhanced in female rats. On the other hand, the activities toward various xenobiotics in male rats were unchanged. When 3-methylcholanthrene was given to rats for a week, the augmentation of cytochrome P-450 content and the stimulation ofxenobiotic metabolism were observed. However, co-administration ofTJ-9 did not alter the effect of 3-methylcholanthrene described above.Keywords
This publication has 0 references indexed in Scilit: