Mutagenicity of metal salts in the L5178Y mouse lymphoma assay

1 March 1982

journal article
research article
Published by Taylor & Francis in Journal of Toxicology and Environmental Health

Vol. 9 (3) , 367-376
https://doi.org/10.1080/15287398209530170

Abstract

Metals (11) were examined for their potential to induce forward mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. The materials tested included AlCl3, CdSO4, HgCl4, K2CrO4, K2Cr2O7, MgCl2, MnCl2, NaAsO2, Na2HAsO4, NaCl and Pb(NO3)2. Strong positive responses at survivals > 10% were observed with CdSO4, K2CrO4, K2Cr2O7 and MnCl2. Weak positive responses, yielding 2- to 3-fold increases in mutation frequency above the solvent control at > 10% survival, were seen with HgCl2, NaAsO2, Na2HAsO4 and Pb(NO3)2. Negative responses were obtained with MgCl2, NaCl and AlCl3. [This study may be applicable to human carcinogenesis/environmental pollutants.].

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