Carboxyhemoglobin Levels in an Unstable Hemoglobin Disorder (Hb Zürich): Effect on Phenotypic Expression
- 18 July 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4454) , 406-408
- https://doi.org/10.1126/science.7384813
Abstract
The affinity of Hb Zurich for carbon monoxide is approximately 65 times that of normal hemoglobin. The carboxyhemoglobin content in serum from individuals with Hb Zurich ranged from 3.9 to 6.7 percent in nine nonsmokers and from 9.8 to 19.7 percent in six smokers. Rates of hemolysis and hemoglobin denaturation were less in smokers than in nonsmokers, effects that may be secondary to the stabilization of Hb Zurich by carbon monoxide.Keywords
This publication has 14 references indexed in Scilit:
- Aquopentacyanoferrate(II): An effective probing electron donor in the conversion of oxyhemoglobin to methemoglobin and peroxideBiochemical and Biophysical Research Communications, 1979
- Smokers' PolycythemiaNew England Journal of Medicine, 1978
- Properties of hemoglobin a and hemoglobin Zurich (β63 histidine→arginine): Quantitative evaluation of functional abnormalities in hemoglobinsBiochemical and Biophysical Research Communications, 1976
- The utility of infrared spectroscopy as a probe of intact tissue: Determination of carbon monoxide and hemeproteins in blood and heart muscleBiochemical and Biophysical Research Communications, 1974
- Hemoglobin Zürich: A third family presenting with hemolytic reactions to sulfonamidesThe American Journal of Medicine, 1973
- Hemoglobin stability: observations on the denaturation of normal and abnormal hemoglobins by oxidant dyes, heat, and alkaliJournal of Clinical Investigation, 1970
- Differences in the infrared stretching frequency of carbon monoxide bound to abnormal hemoglobinsBiochemistry, 1969
- Endogenous carbon monoxide production in patients with hemolytic anemia.Journal of Clinical Investigation, 1966
- Hemoglobin Zürich: Clinical, chemical and kinetic studiesThe American Journal of Medicine, 1965
- Effect of Erythrocyte Destruction on Carbon Monoxide Production in Man*Journal of Clinical Investigation, 1964