ERYTHROCYTOTOXICITY INDUCED BY CANCER CHEMOTHERAPEUTIC-AGENTS - INVITRO STUDIES OF OSMOTIC FRAGILITY AND METHEMOGLOBIN GENERATION

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 25  (4) , 363-368
Abstract
Increased osmotic fragility and methemoglobin generation in vitro have resulted from the exposure of normal human erythrocytes to numerous cancer chemotherapeutic agents. These findings offer a possible explanation for the earlier, consistent clinical observation of the rapid development of anemia, during consolidation therapy, in children with acute lymphoblastic leukemia in remission.