Influence of blood oxygen saturation on pressure-flow curve of dog hindleg

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Abstract
The theory that vascular beds are capable of adjusting their resistance in order to assure an adequate supply of O2 to the tissues which they supply has been subjected to experimental study. The pressure-flow curves of isolated dog hindlegs were determined at several levels of O2 saturation of the perfusing blood. The results indicate that within the ranges of about 50-150 mm Hg perfusing pressure and 100-60% arterial blood O2 saturation, the adjustments are very nearly what would be required to assure constant deliver of O2 to the areas under study. The possible mechanisms and the significance of these observations are discussed.

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