α 1 -Antitrypsin Deficiency: A Variant with No Detectable α 1 -Antitrypsin
- 6 July 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 181 (4094) , 70-71
- https://doi.org/10.1126/science.181.4094.70
Abstract
No α 1 -antitrypsin could be detected in the serum of a 24-year-old man with advanced pulmonary emphysema by agarose electrophoresis, immunoelectrophoresis, double diffusion in agarose gel, or α 1 -antitrypsin genetic typing by a combination of starch-gel electrophoresis and crossed antigen-antibody electrophoresis. A circulating α 1 -antitrypsin inactivator could not be demonstrated. Evidence was obtained in family members of genetic transmission of this new α 1 -antitrypsin variant.Keywords
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