Effects of prostaglandin F-2 and E-2 on the production of progesterone by mouse ovaries in vitro

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Abstract
The effects of various doses of PGE2 [prostaglandin E2] and PGF2.alpha., alone and in combination, on the secretion of progesterone by mouse ovaries in vitro, with or without added gonadotropins, were examined. PGE2, even at a seemingly low concentration, can stimulate the production of progesterone by mouse ovaries in vitro. PGF2.alpha. has little effect on steroidogenesis when the tissue is producing little or no progesterone. When ovarian tissue is exposed to gonadotropins which stimulate progesterone secretion, low doses of PGF2.alpha. partly blocked [50%] the stimulatory effect of LH [luteinizing hormone] plus follicle stimulating hormone while high doses enhanced the gonadotrophic effect. PGE2 may modify the steroidogenic response of the follicle to LH and thus ensure that the full steroidogenic potential of the newly forming corpus luteum is expressed.

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