Reduction of the Anaphylaxis Enhancing and Adjuvant Effects of Bordetella Pertussis by a Prior Injection of B. Pertussis

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Abstract
Summary: Mice inoculated with Bordetella pertussis and bovine serum albumin have an enhanced sensitivity to anaphylactic shock when subsequently challenged with BSA. The incidence of anaphylaxis as well as the amount of circulating antibodies to BSA are both significantly reduced in mice injected with pertussis vaccine 5 days prior to sensitizing injections of pertussis vaccine and BSA. A prior injection of B. pertussis also significantly reduces the incidence of anaphylaxis in mice sensitized with BSA in Freund's adjuvant.