MYOGLOBIN, CREATINE-KINASE AND ITS ISOENZYME MB IN SERUM AFTER ACUTE MYOCARDIAL-INFARCTION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 8  (4-5) , 515-521
Abstract
Serum creatine kinase, creatine kinase MB and myoglobin were determined in patients suffering from acute myocardial infarction (AMI) with shorter duration of symptoms than 6 h. At time of admission, 83% had increased concentrations of myoglobin while 28% had creatine kinase values above the reference limit. After onset of symptoms, peak levels were found after 9.4 h (myoglobin) and 23.0 h (creatine kinase). Maximal levels of myoglobin and creatine kinase divided by upper reference limits correlated positively and were approximately of the same quantitative sensitivity in AMI. Compared to myoglobin, creatine kinase and its isoenzyme showed approximately the same appearance = disappearance ratio. This study demonstrates myoglobin to be an early and sensitive indication of AMI.

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