Asymmetric Hydrogenation of α-Keto Acid Derivatives with Rh(I)–Chiral Diphosphinite System. Effect of Halide Counterion on the Asymmetric Induction
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 63 (1) , 281-283
- https://doi.org/10.1246/bcsj.63.281
Abstract
A chiral diphosphinite ligand having dicyclohexylphosphinooxy and dimethylamino moieties (Cy-POP-AE) was effective for the asymmetric hydrogenation of N-(benzoylformyl) amino acids by a Rh(I) catalyst under mild conditions. A neutral rhodium(I) precursor enabled a double asymmetric induction in methanol, while a cationic precursor caused an asymmetric induction controlled mainly by the substrate chirality.Keywords
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