Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era

Publisher Website
Google Scholar
Abstract
Objectives: To compare mortality and death or major morbidity (DOMM) among infants Study design and patients: Comparative cohort study of very low birthweight (501–1500 g) infants Results: Mortality was higher for group I (63.1% v 56.7%; p = 0.0006). Antenatal steroids (ANS) and antenatal antibiotics (AABX), surfactant (pv 88.4%; p = 0.2), but risk was lower for group I in regression models that included ANS (OR 0.70, 95% CI 0.52 to 0.94). Conclusion: Survival to discharge was more likely during the more recent period because of group differences in ANS, AABX, and surfactant. However, this treatment shift may reflect an overall more aggressive management approach. More consistent application of treatment has led to improving survival of <25 week EGA infants during the post-surfactant era, but possibly at the cost of greater risk of major in-hospital morbidities.

This publication has 33 references indexed in Scilit: