Determination of D-Penicillamine and Its Metabolites in Blood and Urine
Open Access
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 102 (4) , 322-327
- https://doi.org/10.1248/yakushi1947.102.4_322
Abstract
The time courses of concentrations of D-penicillamine (PA) and its metabolites PA disulfide [PSSP], PA-cysteine [PSSC], S-methyl PA [MeSP] in the blood and urine of rat, dog and man were determined by using a high-performance liquid chromatography with a voltammetric detector (LC-VMD) and an amino acid analyzer. The blood level of PA was highest 2 h after the oral administration of PA, and the man metabolite was PSSC in all animals. Biological half-lives (T12) of PA were 0.83 h (rat), 0.71 h (dog) and 1.13 h (men). The main metabolites in the urine were PSSC, PSSC in dog and PSSC in men.Keywords
This publication has 5 references indexed in Scilit:
- High-performance liquid chromatographic determination of penicillamine in whole blood, plasma, and urineJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- Determination of penicillamine in blood and urine by high performance liquid chromatographyAnalytical Chemistry, 1978
- Studies on d-penicillamine metabolism in cystinuria and rheumatoid arthritis: Isolation of S-methyl-D-penicillamineBiochemical Pharmacology, 1976
- Computer Program for a Double Exponential Equation to Determine Biological ConstantsJournal of Pharmaceutical Sciences, 1967
- Rheumatoid Arthritis with ArteritisAnnals of Internal Medicine, 1964