Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout
Open Access
- 1 July 1988
- journal article
- other
- Published by Taylor & Francis in Veterinary Quarterly
- Vol. 10 (3) , 211-216
- https://doi.org/10.1080/01652176.1988.9694173
Abstract
The plasma disposition of ciprofloxacin was studied in carp, African catfish and trout after intravenous (IV) and intramuscular (IM) administration at a dose rate of 15 mg/ kg. Pharmacokinetic analysis of IV data showed that ciprofloxacin was well distributed (distribution volume V area): 3.08 ‐ 5.59 litre/kg) and exhibited a similar elimination half‐life of about 14 h in these 3 fish species. After IM administration to carp and trout a rapid absorption was noticed; the maximum ciprofloxacin plasma concentrations (mean: 3.49 and 2.37 pg/ml, respectively), were achieved within I h after injection. At the dose level applied, ciprofloxacin has potential therapeutic value for 2–5 days especially against gram‐negative bacterial fish pathogens.This publication has 3 references indexed in Scilit:
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- The influence of antibiotics on the immune system: immuno-pharmokinetic investigations on the primary anti-SRBC response in carp, Cyprinus carpio L., after oxytetracycline injectionJournal of Fish Diseases, 1987
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