Brain Catecholamines and Their Metabolites in Parkinsonian Patients
- 1 February 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 28 (2) , 107-110
- https://doi.org/10.1001/archneur.1973.00490200055007
Abstract
Analyses of autopsy samples of parkinsonian patients showed significantly decreased concentrations of dopamine and homovanillic acid (HVA) in extrapyramidal brain regions. Twelve patients treated with levodopa alone or combined with a decarboxylase inhibitor showed concentrations of dopamine and HVA which ranged from values corresponding to nontreated parkinsonian patients to levels above those in controls. Increase of concentration of HVA was relatively more marked than that of dopamine. There were no significant changes in the concentration of noradrenaline. Histological examination of brain samples showed no changes related to the treatment.Keywords
This publication has 9 references indexed in Scilit:
- Cerebral Catecholamines After Levodopa TherapyArchives of Neurology, 1971
- L-Dopa Treatment in Parkinson’s DiseaseEuropean Neurology, 1970
- Modification of Parkinsonism — Chronic Treatment with L-DopaNew England Journal of Medicine, 1969
- ParkinsonismNeurology, 1967
- Zur Biochemie des Parkinson-Syndroms des MenschenKlinische Wochenschrift, 1963
- Effect of iproniazid on monoamines and monoamine oxidase in human brainCellular and Molecular Life Sciences, 1962
- Verteilung des 5-Hydroxytryptamins (Serotonin) im Gehirn des Menschen und sein Verhalten bei Patienten mit Parkinson-SyndromKlinische Wochenschrift, 1961
- Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen SystemsJournal of Molecular Medicine, 1960
- A Fluorimetric Method for the Determination of Dopamine (3‐Hydroxytyramine.)Acta Physiologica Scandinavica, 1958