The functional Myosin Light Chain Kinase (MYLK) gene localizes with marker D3S3552 on human chromosome 3q21 in a >5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes
- 2 April 2001
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 92 (1-2) , 85-88
- https://doi.org/10.1159/000056874
Abstract
The myosin light chain kinase (MYLK) gene is duplicated on human chromosome 3 (3q13→q21; 3p13), two sites known to contain olfactory receptor (OR) genes. The 3p13 site contains a MYLK pseudogene (MYLKP) associated with a cluster of OR pseudogenes and therefore could have arisen from the duplication of a large region in 3q13→q21. Here, we present the localization of the MYLK gene in a >5-Mb region of the chromosome 3q21 integrated map. MYLK colocalizes with marker D3S3552. OR genes are absent from this region, suggesting that the 3p13 duplicated region incurred further rearrangements during evolution.Keywords
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