Hyperaldosteronism and Renal Sodium Loss Reversed by Drug Treatment for Malignant Hypertension

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Abstract
SOME patients with renal disease, with1 and without2 hypertension, cannot conserve sodium normally. The loss of sodium leads to an increased production of aldosterone, but the relation of the increased aldosterone production to the defective sodium conservation is not always clear, for the hyperaldosteronism may persist even when large amounts of sodium are given.2 , 3 This could be explained if the high sodium intake did not produce and maintain a normal volume of extracellular fluid in such patients. It could also be explained if the hyperaldosteronism were caused by a condition other than "sodium wasting."It has been suggested that malignant . . .