Inhibitory Effects of Hyaluronan on (14C)Arachidonic Acid Release from Labeled Human Synovial Fibroblasts.
- 1 January 1992
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 60 (2) , 79-84
- https://doi.org/10.1254/jjp.60.79
Abstract
The effects of hyaluronan (HA) on the release of arachidonic acid (AA) from phospholipids induced by bradykinin in synovial fibroblasts of osteoarthritic patients were examined. HA inhibited [14C]AA release from prelabeled synovial cells stimulated with and without bradykinin 1 hr after incubation with HA and thereafter. The inhibitory effects of HA on [14C]AA release were dependent on the concentration and molecular weight of HA. However, inhibition of [14C]AA release by HA was not merely due to the viscosity of HA. The [14C]AA release induced by calcium-ionophore A23187 was also inhibited by HA with a high molecular weight. In addition, HA did not affect [14C]AA uptake by the cells. Our results suggest that HA with a high molecular weight elicits anti-inflammatory effects, at least in part, by inhibiting AA release in inflamed joints.Keywords
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