THE PROLONGATION OF RENAL ALLOGRAFT SURVIVAL BY AN IMMUNOSUPPRESSIVE PEPTIDE ISOLATED FROM HUMAN PLASMA

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Abstract
Immunoregulatory α-globulin (IRA), a naturally occurring immunosuppressive peptide isolated from pooled normal human plasma, was administered to Lewis rats before allografting of LBNF1 kidneys. Control Lewis rats received either no treatment or inactive human peptide before kidney allografting. Median survival was 10.0 ± 2.2 (SD) days and 9.0 ± 1.0 days in Lewis rats receiving inactive peptide or no treatment, and 21.0 ± 1.9 days in Lewis recipients treated with IRA, P

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