Cell Death or Synaptic Loss in Alzheimer Disease
Open Access
- 1 December 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 59 (12) , 1118-1119
- https://doi.org/10.1093/jnen/59.12.1118
Abstract
It is an erroneous but common assumption that loss of neuronal perikarya causes the cognitive change in Alzheimer disease. Neither are senile plaques nor neurofibrillary tangles primarily to blame. In fact, it is the loss of synaptic contact that leads directly to the personal devastation. The death of neocortical synapses in the neuropil between plaques is probably the factor that activates the microglia.Keywords
This publication has 6 references indexed in Scilit:
- Overexpression of tau protein inhibits the outward flow of vesicles and organelles along microtubulesNeurobiology of Aging, 2000
- Mechanisms of cell death in Alzheimer’s diseasePublished by Springer Nature ,1997
- Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentAnnals of Neurology, 1991
- Some morphometric aspects of the brain in senile dementia of the alzheimer typeAnnals of Neurology, 1981
- The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia*†Journal of Neuropathology and Experimental Neurology, 1967
- Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementiaActa Neuropathologica, 1967