Metabolism of 17α-Methylandrostenediol and 17α-Methyltestosterone by the Rat Adrenal Glandin Vitro

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Abstract
Rat adrenal tissue in vitro oxidized 17[alpha]-methylandrost-5-ene-3[beta], 17[beta]-diol (MAD) to 17[alpha]-methylandrost-4-en-17[beta]-ol-3-one (17[alpha]-methyltestosterone). Both MAD and 17[alpha]-methyltestosterone were further metabolized to at least 5 ultraviolet light-absorbing products. Evidence was obtained for the identification of the major product as ll[beta]-hydroxy-17[alpha]-methyltestosterone. The next most abundant product was probably 11-oxo-17[alpha]-methyltestoster-one. The other products were formed in lesser amounts and little progress was made in their identification. The metabolism of 17[alpha]-methyltestosterone to these metabolites was strongly inhibited by the addition of Metopirone to the incubation medium, suggesting that hydroxylation is a major pathway of metabolism.

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