Transglutaminase and diseases of the central nervous system
- 1 January 2005
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 10 (1-3) , 3078-92
- https://doi.org/10.2741/1764
Abstract
Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.Keywords
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