Hepatic Glutathione Reductase and Riboflavin Concentrations in Experimental Deficiency of Thiamin and Riboflavin in Rats

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Abstract
Effects of thiamin and riboflavin deficiency on hepatic riboflavin levels and glutathione reductase activity were studied. Hepatic glutathione reductase did not show any change after 3 weeks of thiamin, riboflavin or pyridoxine deficiency, though the riboflavin concentration of thiamin-deficient animals was significantly higher and that of riboflavin-deficient animals markedly lower than control animals. In a longitudinal experiment, erythrocyte glutathione reductase was found to be more sensitive to riboflavin deficiency than liver glutathione reductase, though riboflavin level of the liver diminished at a faster rate than that of the erythrocyte. Hepatic xanthine oxidase was more sensitive than glutathione reductase. Liver glutathione reductase of riboflavin-deficient animals could not be stimulated by the in vitro addition of FAD.