Effect of Trimethoprim-Sulphamethoxazole Combination on Folate Metabolism in Malnourished Children
Open Access
- 1 August 1972
- journal article
- review article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 47 (254) , 626-630
- https://doi.org/10.1136/adc.47.254.626
Abstract
The effect of a 10-day course of trimethoprim-sulphamethoxazole on folate metabolism was studied in 10 children with severe protein-calorie malnutrition. There was a significant increase in formimino-glutamic acid (FIGLU) excretion after a histidine load in children treated with trimethoprim-sulphamethoxazole, when compared with a control group, but no haematological evidence of folate deficiency.Keywords
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