Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Top Cited Papers
- 18 November 2007
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 10 (12) , 1538-1543
- https://doi.org/10.1038/nn2014
Abstract
Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.Keywords
This publication has 44 references indexed in Scilit:
- Origin of dendritic cells in peripheral lymphoid organs of miceNature Immunology, 2007
- Origin and distribution of bone marrow‐derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosisGlia, 2006
- Microglial cell activation and proliferation precedes the onset of CNS autoimmunityJournal of Neuroscience Research, 2005
- Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in VivoScience, 2005
- Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microgliaThe FASEB Journal, 2004
- Hematopoietic origin of microglial and perivascular cells in brainExperimental Neurology, 2004
- Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis studyCanadian Journal of Physiology and Pharmacology, 2002
- Microglia: a sensor for pathological events in the CNSTrends in Neurosciences, 1996
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisNature, 1993
- Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in VivoScience, 1988