COMPARISON OF THE VASODILATOR ACTION OF DOPAMINE AND DOPAMINE AGONISTS IN THE RENAL AND CORONARY BEDS OF THE DOG

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Abstract
The effects of dopamine and the dopamine receptor agonists, SK&F 38393 [2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] and bromocriptine, on renal and coronary blood flow in the anesthetized dog were examined. Dopamine dilated both vascular beds, whereas SK&F 38393 increased renal blood flow but did not have any dilator activity in the coronary vasculature. Bromocriptine did not cause vasodilatation in either vascular bed. The vasodilator responses to dopamine and SK&F 38393 were significantly reduced by the dopamine receptor antagonists, ergometrine or metoclopramide. The selective action of SK&F 38393 on the renal vasculature suggests that the dopamine receptors of the renal and coronary vascular beds may be of different types.