Nonidentical Twins with a Single Placenta — Disproving Dogma in Perinatal Pathology

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Abstract
Generations of trainees have been taught that monochorionic twin placentas are monozygotic. A report by Souter et al. in this issue of the Journal (pages 154–158) invalidates this simple rule by convincingly demonstrating the association of a monochorionic placenta with dizygotic twins. A brief review of the current understanding of twin pregnancy may help to put this new finding into perspective.Dizygotic, or fraternal, twins develop from two separate fertilized eggs, whereas monozygotic, or identical, twins are derived from a single fertilized egg that has divided to form separate embryos (see Figure). The rate of monozygotic twinning is relatively stable . . .

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