The Neuropathology of Experimental Vitamin B6Deficiency in Monkeys

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Abstract
The neuropathologic changes in pyridoxine-deprived monkeys are described. The most prominent abnormalities are seen in the large nerve cells of the cerebral cortex, which show swelling, eccentricity of nuclei, and loss of the Nissl particles. This cell change bears a strong resemblance to that seen in human pellagra. The preliminary nature of these observations is stressed. The significance of the nerve cell change itself and the specificity of this change in pyridoxine deficiency are still in doubt; observations on considerably more experimental animals are required to settle these matters.