Pulmonary Allergie Aspergillosis

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Abstract
In pulmonary allergic aspergillosis the fungus grows in secretions of the respiratory tract. Its pathogenesis results from two types of hypersensitivity to aspergillus immediate, due to reaginic antibody, and toxic-complex, due to precipitating antibody. Both types were present in the serum of the first such case of a patient with pulmonary allergic aspergillosis reported in North America. The immediate and toxic-complex types of reactivity were transferred to the skin of rhesus monkey recipients. Passive systemic transfer to a rhesus recipient was accomplished by infusion of the patient's serum followed by aerosol challenge with aspergillus antigen. The recipient animal developed cutaneous reactivity and pulmonary lesions consistent with the donor's illness. Clinical manifestations of the patient were intermittent fever and cough with peripheral blood and sputum eosinophilia and fluctuating pulmonary infiltrates. The respiratory secretions contained Aspergillus fumigatus, but no evidence of lung tissue invasion was demonstrated by X ray or biopsy. The disease cleared rapidly with prednisone therapy and has remained absent for 2½ years after treatment.

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