The nature of Langerhans cell granules: an ultrastructural study

Publisher Website
Google Scholar
Abstract
Langerhans cells and macrophages have been studied in both oral lichen planus lesions and histiocytosis X. Many of the macrophages in both lesions contained phagolysosomes in various stages of degradation. Some of these phagolysosomes developed slender processes and very narrow extensions containing little processed phagocytosed material. These latter structures were indistinguishable from Langerhans granules and were termed Langerhans granule-like structures. Typical Langerhans granules apparently evolve from Langerhans granule-like structures and Langerhans cells are confirmed to be a type of macrophage which at 1 stage of their development show Langerhans granules.