Cross‐Serotype Neutralization of Dengue Virus inAotusnancymaeMonkeys
Open Access
- 15 March 2005
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 191 (6) , 1000-1004
- https://doi.org/10.1086/427511
Abstract
Previously, we observed that serum from humans immune to dengue serotype 1 (dengue-1) neutralized the American genotype of dengue serotype 2 (American-2) to a greater extent than it neutralized the Asian genotype of dengue serotype 2 (Asian-2). To determine if this activity is protective, Aotus nancymae monkeys were infected with dengue-1 followed by either American-2 or Asian-2. Dengue-1–infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue-1, 409 against American-2, and <20 against Asian-2. Infection with American-2 did not produce detectable viremia in either dengue-1–immune or dengue-1–naive animals. These findings support the hypothesis that dengue-1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 and American-2Keywords
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