Isolation of an antidermatophytic substance from the root of Salvia miltiorrhiza.

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Abstract
Dihydrotanshinone I was isolated from a Chinese crude drug "Danshen" (the root of Salvia miltiorrhiza) as an antidermatophytic substance against Trichophyton mentagrophytes. This compound inhibited the mycelial growth of six dermatophytes completely at a concentration as low as 1.56 to 6.25 .mu.g/ml, depending on species, whereas its congener cryptotanshinone was found to be active only against T. tonsurans var. sulfureum at 100 .mu.g/ml. Cryptotanshinone, however, was as active as dihydrotanshinone I against four species of gram-positive bacteria at 0.195-50 .mu.g/ml.

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