Transposition of the Great Arteries

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Abstract
TRANSPOSITION of the great arteries is one of the most serious of congenital heart defects. It is not a rare anomaly. The incidence is reported as 1 in 11,000 births by Keith et al.1 and as 7.4 per cent of autopsy cases of congenital heart disease by Abbott.2 The mortality is high, being reported by Keith and his co-workers3 as 85 per cent in the first six months of life. Much has been written about the clinical,1 , 3 4 5 6 7 8 9 10 anatomic,11 12 13 14 15 radiologic16 , 17 and angiocardiographic18 19 20 21 features. Comparatively little has appeared in the literature regarding the pathophysiology.1 , 22 23 24 25 26 Keith and his associates,3 Gasul and Marienfeld,5 Blalock . . .