The Anticonflict Effect of MK-801, an NMDA Antagonist: Investigation by Punishment Procedure in Mice
Open Access
- 1 January 1990
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 54 (2) , 250-252
- https://doi.org/10.1254/jjp.54.250
Abstract
The NMDA antagonist MK-801 at 0.3 mg/kg, i.p. increased the punished response under a MUTL VI 1.5/FR 5-punishment schedule of food reinforcement in mice. Furthermore, although neither MK-801 (0.1 mg/kg, i.p.) nor diazepam (0.25 mg/kg, s.c.) was without effect when separately administered, a significant increase in the punished response appeared after the combined administration of these two drugs. The present results suggest that MK-801 not only shows an anticonflict effect, but also enhances the anticonflict effect of benzodiazepine anxiolytics in mice.This publication has 5 references indexed in Scilit:
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- Effect of the benzodiazepine receptor antagonist Ro 15-1788 on the anticonvulsant and anticonflict actions of MK-801European Journal of Pharmacology, 1982
- Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 1982
- Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 1982
- Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 1982