REINSTATEMENT OF RESPONDING MAINTAINED BY COCAINE OR THIAMYLAL

  • 1 January 1984
    • journal article
    • research article
    • Vol. 228  (1) , 43-52
Abstract
Rhesus monkeys [Macaca mulatta] were trained to self-administer 1 of 2 reference drugs, either cocaine or thiamylal. The lowest dose of cocaine or thiamylal which maintained responding was determined. Responding extinguished when saline was substituted for a reference drug. Subsequently, the effects of a variety of otther drugs on saline self-administration were determined. In the cocaine-trained monkeys, the i.m. administration of d-methylamphetamine, cocaine, morphine or codeine during a session reinstated responding for saline infusions; naloxone, chlorpromazine, dimethyltryptamine, diazepam and secobarbital did not. Naloxone blocked responding produced by the i.m. administration of morphine. In the thiamylal-trained monkeys, the administration of secobarbital (i.m.), pentobarbital (p.o. [oral]), butabarbital (p.o.) and phenobarbital (p.o.) reinstated responding for saline. The onset of behavioral responding was related to the pharmacokinetic properties of the drugs, with phenobarbital > pentobarbital = butabarbital. Cocaine and d-amphetamine i.m. failed to reinstate the responding in monkeys which were trained to self-administer thiamylal. Drugs producing responding at a rate significantly greater than that produced by vehicle controls apparently share reinforcing properties with the reference drug.