Cp2Fe(PR2)2PdCl2 (R = i-Pr, t-Bu) Complexes as Air-Stable Catalysts for Challenging Suzuki Coupling Reactions
- 17 September 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (21) , 3731-3734
- https://doi.org/10.1021/ol048598t
Abstract
The use of Cp2Fe(PR2)2PdCl2 (R = i-Pr and t-Bu) in Suzuki coupling reactions were illustrated using a high throughput screening approach. The di-tbpfPdCl2 catalyst was shown to be the more active catalyst for unactivated and sterically challenging aryl chlorides. Comparison studies using the commercial catalysts dppfPdCl2, (Ph3P)2PdCl2, (Cy3P)2PdCl2, DPEPhosPdCl2, dppbPdCl2, dppePdCl2, Pd(t-Bu3P)2, and [Pd(μ-Br)(t-Bu3P)]2 were also done for selected cases to demonstrate the superior activities of di-tbpfPdCl2 and di-isoppfPdCl2.Keywords
This publication has 16 references indexed in Scilit:
- A General Method for the Suzuki−Miyaura Cross-Coupling of Sterically Hindered Aryl Chlorides: Synthesis of Di- and Tri-ortho-substituted Biaryls in 2-Propanol at Room TemperatureJournal of the American Chemical Society, 2003
- Scope and Mechanism of Palladium-Catalyzed Amination of Five-Membered Heterocyclic HalidesThe Journal of Organic Chemistry, 2003
- Reactivity studies of [Pd2(μ-X)2(PBut3)2] (X = Br, I) with CNR (R = 2,6-dimethylphenyl), H2 and alkynesJournal of Organometallic Chemistry, 2000
- Versatile Catalysts for the Suzuki Cross-Coupling of Arylboronic Acids with Aryl and Vinyl Halides and Triflates under Mild ConditionsJournal of the American Chemical Society, 2000
- Bidentate ferrocenylphosphines and their palladium(II)dichloride complexes — X-ray structural and NMR spectroscopic investigations and first results of their characteristics in the Pd-catalysed cooligomerisation of 1,3-butadiene with CO2Journal of Organometallic Chemistry, 2000
- Simple, Highly Active Palladium Catalysts for Ketone and Malonate Arylation: Dissecting the Importance of Chelation and Steric HindranceJournal of the American Chemical Society, 1999
- Palladium-catalyzed synthesis of triarylamines from aryl halides and diarylaminesTetrahedron Letters, 1998
- Synthesis, single crystal X-ray structure determination and NMR studies of Cp2Fe(PPh2)2PtPh2 and Cp2Fe(PPh2)2PtI2Journal of Organometallic Chemistry, 1998
- Dichloro(3-isopropyl-1,2,4,5,5-pentamethylcyclopenta-1,3-diene)platinum(II)Acta Crystallographica Section C Crystal Structure Communications, 1992
- 1,1'-Bis(alkylarylphosphino)ferrocenes: synthesis, metal complex formation, and crystal structure of three metal complexes of Fe(.eta.5-C5H4PPh2)2Organometallics, 1985