The Experimental Transmission of Poliomyelitis to the Eastern Cotton Rat, Sigmodon hispidus hispidus

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Abstract
A strain of poliomyelitis virus isolated from a bulbar case of poliomyelitis at Lansing, Mich., 1937, has been conveyed through 7 successive passages in the cotton rat. The incubation period ranged from 4 to 29 days, usually 5 to 8 days in later transfers. Flaccid paralysis of one or more limbs, and in some intances respiratory failure, occurred. The pathology is a polioencephalitis consistent with lesions found in man and monkeys.

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