Transfusion-Induced Specific Anti–Factor XI Inhibitor in a Patient with Previously Unrecognized Factor XI Deficiency
Open Access
- 1 March 1988
- journal article
- case report
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 89 (3) , 418-422
- https://doi.org/10.1093/ajcp/89.3.418
Abstract
This article reports the rare occurrence and investigation of a specific anti–factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. The IgG fraction of the patient’s plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel® and concentrated. It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay.Keywords
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