Cytotoxic T lymphocytes as immune‐therapy in haematological practice
Open Access
- 24 September 2008
- journal article
- review article
- Published by Wiley in British Journal of Haematology
- Vol. 143 (2) , 169-179
- https://doi.org/10.1111/j.1365-2141.2008.07316.x
Abstract
Viral infections are a significant cause of morbidity and mortality, particularly in pediatric allogeneic haematopoietic stem cell transplant recipients. Effective therapies are limited and often associated with significant side effects. Adoptive transfer of virus‐reactive T cells offers a means of reconstituting antiviral immunity and this approach has been successfully used to prevent and treat cytomegalovirus, Epstein‐Barr virus, and adenovirus infections in vivo. This review outlines the clinical trials that have been performed to date, and will describe future initiatives to (a) develop strategies that can increase the breadth of the viruses that can be targeted, and (b) simplify the process to extend this technology to more centers so that cellular therapy to reconstitute immunity can be more widely applied.Keywords
This publication has 88 references indexed in Scilit:
- Exploiting Cytokine Secretion to Rapidly Produce Multivirus-specific T Cells for Adoptive ImmunotherapyJournal of Immunotherapy, 2008
- CD134-Allodepletion Allows Selective Elimination of Alloreactive Human T Cells without Loss of Virus-Specific and Leukemia-Specific EffectorsTransplantation and Cellular Therapy, 2008
- A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion techniqueBlood, 2008
- Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccineVaccine, 2008
- Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and ImmunotherapyJournal of Virology, 2008
- Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infectionBlood, 2007
- Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantationBlood, 2006
- In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytesBlood, 2006
- High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCTBlood, 2006
- Safe adoptive transfer of virus‐specific T‐cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantationBritish Journal of Haematology, 2006