Studies on Urinary Lipase
- 1 October 1959
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Internal Medicine
- Vol. 104 (4) , 568-573
- https://doi.org/10.1001/archinte.1959.00270100054009
Abstract
In the course of our studies on urinary lipase1-3we presented evidence that a fatsplitting enzyme was present regularly in the urine of man. Concentration of the enzyme ranged from 0.1 to 0.75 units, that is, 0.1 cc. to 0.75 cc. of N/20 sodium hydroxide has been required to titrate liberated fatty acids from a urine-olive oil mixture, incubated for 24 hours to a pink end-point with phenolphthalein. In patients where the values have been found elevated, that is, higher than 1.0 unit, there were symptoms or laboratory findings or both which pointed to pancreatic disease. In patients with carcinoma of the pancreas, however, values for urinary lipase were less than 1 unit. The same patients had normal values for serum and urinary diastase. The finding that the values for urinary lipase did not show any change from the normal in carcinoma of the pancreas was of no helpThis publication has 0 references indexed in Scilit: