Mode of action of the 2-nitroimidazole derivative benznidazole
- 1 February 1978
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 72 (1) , 45-54
- https://doi.org/10.1080/00034983.1978.11719278
Abstract
Using cultures of Trypanosoma cruzi cells in a liquid medium, the mode of action of the 2-nitroimidazole derivative benznidazole was examined. Benznidazole inhibits protein synthesis and RNA synthesis in T. cruzy. The DNA synthesis is only slightly decreased and no effect on the aerobic respiration of T. cruzi was observed.Keywords
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