STUDIES ON LOW INSULIN RESPONDERS

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Abstract
The insulin responses to intravenous glucose infusion (GIT) and oral administration of glucose (OGTT) were measured in 226 control subjects and 25 chemical or mild maturity-onset non-obese diabetics. In addition, intravenous glucose tolerance tests (IVGTT) were performed in all subjects. The insulin response to GIT was analyzed by parameter identification in a mathematical model. This model assumes that glucose initiates insulin release by an immediate action, the magnitude of which is given by parameter KI. In addition, glucose induces a time-dependent potentiation (KP) of its initiating action. Insulin release is also modulated by negative feedback inhibition (KB), which displays an intermediary time course between KI and KP. The computer analysis of GIT allows the identification of a further parameter, KG, which defines sensitivity to endogenous insulin. In addition, a hypothetical plasma insulin value at 10 min was calculated, called IP, and reflecting the response to a standard glucose stimulation. Finally, the insulinogenic index (ΔI/ΔG) for the 10 min value of GIT was calculated.

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