Weekly Mitoxantrone Therapy of Hodgkinʼs Disease, Non-Hodgkinʼs Lymphoma, and Chronic Lymphocytic Leukemia A Southeastern Cancer Study Group Trial

Abstract
A weekly schedule of mitoxantrone was evaluated in chronic lymphoproliferative disorders. One of 11 patients with Hodgkin''s disease, 2 of 12 with favorable-histology non-Hodgkin''s lymphoma, 4 of 27 with unfavorable-histology non-Hodgkin''s lymphoma, and 1 of 11 with chronic lymphocytic leukemia showed a response. Since the use of a larger single dose every 3 weeks is well tolerated, simpler, and probably more effective, we do not recommend further evaluation of the weekly dose schedule.

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