PROSTAGLANDIN SYNTHETASE INHIBITORS IN THE TREATMENT OF NEPHROGENIC DIABETES INSIPIDUS

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Abstract
Monn, E. (Department of Paediatrics, Rikshospitalet, University of Oslo, Oslo, Norway). Prostaglandin synthetase inhibitors in the treatment of nephrogenic diabetes insipidus. Acta Paediatr Scand, 70:39, 1981.–Two boys with classical ND1 have been treated with prostaglandin synthetase inhibitors. A boy, 7 years old, was treated with low solute‐load diet and diuretics from his first year of life. His main complaint was nocturnal enuresis. He responded within one day to indomethacin 25 nig twice daily, and the urine volume was reduced from 4½‐6 litre/day to 2½‐3 litre/day. There is almost no enuresis. A boy, 7 months old, had a basal daily urine volume of 1.6‐1.8 litre. A low solute‐load diet and diuretics reduced urine volume to 1 litre, but he still needed gastric tube feeding. With the addition of acetylsalicylic acid, 75 mg three times daily, the urine volume was reduced to 600 ml, and he needed no more tube feeding. Both boys are doing well on the above‐mentioned regimens, and no side effects have been observed after 1 year of treatment.

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